Development of Gabapentin Expandable Gastroretentive Controlled Drug Delivery System
نویسندگان
چکیده
منابع مشابه
Development and optimization of metoprolol succinate gastroretentive drug delivery system.
Metoprolol succinate (MS) gastroretentive (GR) controlled release system was formulated to increase gastric residence time leading to improved drug bioavailability. Box-Behnken model was followed using novel combinations of sodium alginate (SA), sodium carboxymethylcellulose (NaCMC), magnesium alumino metasilicate (MAS) as independent variables. Floating lag time (Flag), t25, t50, t75, diffusio...
متن کاملAn Overview on Gastroretentive Drug Delivery System
Oral controlled release and site specific drug delivery system has been of great interest in pharmaceutical field to achieve improved therapeutic advantage. Drug absorption in the gastrointestinal tract is a highly variable procedure and prolonging gastric retention of the dosage form extends the time for drug absorption. Gastro retentive drug delivery system is one of such novel approaches to ...
متن کاملGastroretentive Drug Delivery System - a Review
Oral delivery of drugs is by far the most preferable route of drug delivery . Oral-rate controlled drug delivery systems have an important area among novel drug delivery system. But these oral sustained release drug delivery systems suffer greatly due to their short gastric residence time/ gastric emptying time. Whereas prolonged gastric residence increases duration of drug release, reduces dru...
متن کاملFormulation Development and Evaluation of Hydrogel Based Gastroretentive Drug Delivery System of Antihypertensive Drug
Site specific drug delivery has become the important aspect of research. In present study focused has been made to formulate gastroretentive drug delivery (GRDDS) of drugs having narrow absorption window or having good absorption at proximal part of gastrointestinal tract (GIT) to deliver at stomach site. Hydrogel based gastroretentive formulation of ramipril were prepared by gas blowing techni...
متن کاملFloating Drug Delivery of Nevirapine as a Gastroretentive System
A multiple-unit floating drug delivery system based on gas formation technique was developed, in order to prolong the gastric residence time and to increase the overall bioavailability of the dosage form. The floating bead formulations were prepared by dispersing nevirapine together with calcium carbonate in a mixture of sodium alginate and hydroxypropyl methylcellulose solution and then drippi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-48260-8